Publicaciones 2024

Publicaciones 2023

Step-Economic Total Synthesis of Melosatin A from Eugenol. Santiago Bolivar Avila, Gabriela N. Ledesma, Teodoro S. Kaufman, Sebastian A. Testero y Enrique L. Larghi. ACS Omega 8, 23174–23181 (2023).

Efficient Buchwald-Hartwig and Nitrene-mediated Five-membered Ring Closure Approaches to the Total Synthesis of Quindoline. Unexpected Direct Conversion of a Nitro Group Into a Phosphazene". Elida N. Thobokholt, Sebastián O. Simonetti, Teodoro S. Kaufman, Enrique L. Larghi y Andrea B. J. Bracca. RSC Adv. 13, 13715–13724 (2023).

Characterization of the Hydrochloride Salt Hemihydrate as a New Salt of the Antifungal Agent Tioconazole. Aldana B. Moroni, Elena Pérez Mayoral, Diego F. Lionello, Daniel R. Vega, Teodoro S. Kaufman y Natalia L. Calvo. Int. J. Pharm. 637, 122869 (2023).

Selected Aspects of the Analytical and Pharmaceutical Profiles of Nifurtimox. Aldana B. Moroni, Natalia. L. Calvo y Teodoro S. Kaufman. J. Pharm. Sci. 112, 1523-1538 (2023).

A Nuclear Magnetic Resonance-Based Study of the Behavior of the Tautomers of Triclabendazole in DMSO-d6, in the Presence of Water, Duvernis M. Salazar Rojas, Rubén M. Maggio y Teodoro S. Kaufman. J. Mol. Struct. 1283, 135315 (2023).

Solid-state Properties of Nifurtimox. Preparation, Analytical Characterization, and Stability of an Amorphous Phase, Aldana B. Moroni, Elena Pérez Mayoral, Diego F. Lionello, Daniel R. Vega, Teodoro S. Kaufman y Natalia. L. Calvo. Eur. J. Pharm. Biopharm. 184, 25-35 (2023).

Publicaciones 2022

Chemistry for Sustainable Development, Luiz Pereira Ramos y Teodoro S. Kaufman, J. Braz. Chem. Soc. 33, (7 y 8) 609 (2022) DOI: 10.21577/0103-5053.20220070

 Study of the Heat-Mediated Phase Transformations of Praziquantel Hydrates. Evaluation of their Impact on the Dissolution Rate. Duvernis M. Salazar Rojas, Teodoro S. Kaufman y Rubén M. Maggio. Heliyon 8, e11317 (2022).

A Convenient Wittig-Horner Mediated Synthesis of 3-Vinylsulfide Derivatives of Indoles, Nathan P. Brites, Marina Dilelio, Ricardo F. Schumacher, Teodoro S. Kaufman y Claudio C. Silveira, ChemistrySelect 7, 2202201350 (2022).

Conjugation of Carbohydrates with Quinolines: a Powerful Synthetic Tool to Generate New Chemical Entities, Sebastián O. Simonetti, Teodoro S. Kaufman y Enrique L. Larghi, Eur. J. Org. Chem. e202200107 (2022).

Total Synthesis of Aqabamycin G, a Nitrophenyl Indolylmaleimide Marine Alkaloid from Vibrio sp. WMBA, Didier F. Vargas, Teodoro S. Kaufman y Enrique L. Larghi, J. Org. Chem. 87, 13494–13500 (2022).

Synthesis and evaluation of photophysical and electrochemical properties of vinyl chalcogenide derivatives of phenothiazines, Marina Cardoso Dilelio, Bernardo Almeida Iglesias, Teodoro S. Kaufman y Claudio C. Silveira. Dyes Pigments 198, 109982 (2022).

Form Quantitation in Desmotropic Mixtures of Albendazole Bulk Drug by Chemometrics-Assisted Analysis of Vibrational Spectra, Aldana B. Moroni, Daniel R. Vega, Teodoro S. Kaufman y Natalia L. Calvo, Spectrochim. Acta A 265, 120354 (2022).

Publicaciones 2021

Thermal Decomposition of Hexamethylenetetramine: Mechanistic Study and Identification of Reaction Intermediates Via a Computational and NMR Approach. Sebastián O. Simonetti, Teodoro S. Kaufman, Rodolfo M. Rasia, Ariel M. Sarotti y Nicolas Grimblat, Org. Biomol. Chem. 19, 7374-7378 (2021).

Evolution of the Synthesis of Remdesivir. Classical Approaches and Most Recent Advances", Didier F. Vargas, Enrique L. Larghi y Teodoro S. Kaufman, ACS Omega, 6, 19356-19363 (2021).

Eco-Friendly Methoximation of Aromatic Aldehydes and Ketones Using MnCl2.4H2O as an Easily Accessible and Efficient Catalyst, Melina C. Ontivero, Teodoro S. Kaufman, Iván Cortés y Andrea B. J. Bracca. RS Open Sci. 8, 210142 (2021).

First Total Synthesis of Chromanone A, Preparation of Related Compounds and Evaluation of their Antifungal Activity Against Candida albicans, a Biofilm Forming Agent, Iván Cortés, Estefanía Cordisco, Teodoro S. Kaufman, Maximiliano A. Sortino, Laura A. Svetaz and Andrea B. J. Braccaa, RSC Adv. 5, 19587-19597 (2021).

Langmuir-Blodgett Monolayers Holding a Wound Healing Active Compound and its Effect in Cell Culture. A Model for the Study of Surface Mediated Drug Delivery Systems, Luciana Fernández, Ana Lucía Reviglio, Daniel A. Heredia, Gustavo M. Morales, Marisa Santo, Luis Otero, Fabrisio Alustiza, Ana Cecilia Liaudat, Pablo Bosch, Enrique L. Larghi, Andrea B. J. Bracca y Teodoro S. Kaufman, Heliyon 7, e06436 (2021).

A Comprehensive Approach Toward Concomitant Triclabendazole Polymorphism in Pharmaceutical Products, Duvernis Salazar-Rojas, Teodoro S. Kaufman y Rubén M. Maggio, J. Drug Deliv. Sci. Technol. 62, 102386 (2021).

Publicaciones 2020

Furo[3,2-c]coumarins Carrying Carbon Substituents at C-2 and/or C-3. Isolation, Biological Activity, Synthesis and Reaction Mechanisms, Iván Cortés, L. Javier Cala, Andrea B. J. Bracca y Teodoro S. Kaufman. RSC. Adv. 10, 33344-33377 (2020).

Isolation and Synthesis of Cryptosanguinolentine (isocryptolepine), a Bioactive Naturally-occurring Indoloquinoline Alkaloid, Elida N. Thobokholt, Enrique L. Larghi, Andrea B. J. Bracca y Teodoro S. Kaufman. RSC. Adv. 10, 18978-19002 (2020).

Synthesis and Evaluation of Aromatic Methoxime Derivatives Against Five Postharvest Phytopathogenic Fungi of Fruits. Main Structure-Activity Relationships, Iván Cortés, Melina G. Di Liberto, Teodoro S. Kaufman, Marcos G. Derita y Andrea B. J. Bracca. Food Chem. 321, 126701 (2020).

Efficient Synthesis of 4-Sulfanylcoumarins from 3-Bromocoumarins via a Highly Selective DABCO-Mediated One-pot Thia-Michael Addition/Elimination Process, Vitor B. Mostardeiro, Marina C. Dilelio, Teodoro S. Kaufman y Claudio C. Silveira. RSC. Adv. 10, 482-491 (2020).

Preparation and Characterization of a New Solid Form of Praziquantel, an Essential Anthelmintic Drug. Praziquantel Racemic Monohydrate, Duvernis Salazar-Rojas, Rubén M. Maggio y Teodoro S. Kaufman. Eur. J. Pharm. Sci. 146, 105267 (2020).

Rh(III)-Catalyzed C-H Activation-Based First Total Synthesis of 6-O-Methyl Anciscochine, an Alkaloid Isolated from Ancistrocladus tectorius, Didier F. Vargas, Brenda S. Romero, Enrique L. Larghi y Teodoro S. Kaufman. Synthesis 52, 119-126 (2020). 

Publicaciones 2019

Capítulo de libro: Selected Aspects of the Chemical and Biological Profile of Triclabendazole, a Widely used Benzimidazole Fasciolicidal Agent. Teodoro S. Kaufman, en: Advances in Chemistry Research. Volumen 55, Capítulo 2 (2019), Ed.: James C. Taylor, Nova Publishers, Nueva York, EEUU, ISBN 978-1-53616-105-2.

Capítulo de libro: Selected Aspects of the Analytical Chemistry of Amlodipine, a Widely Used Long Acting Calcium Antagonist". Teodoro S. Kaufman, en: Advances in Chemistry Research Volumen 50, pp. 1-73 (2019), Ed.: James C. Taylor, Nova Publishers, Nueva York, EEUU, ISBN 978-1-53614-808-4.

First Total Synthesis of Ampullosine, a Unique Isoquinoline Alkaloid Isolated from Sepedonium ampullosporum, and of the Related Permethyl Ampullosine, Didier F. Vargas, Enrique L. Larghi y Teodoro S. Kaufman. RSC Adv. 9, 33096-33106 (2019).

Convergent First Total Synthesis of Melovinone, a Densely Substituted 3-Methoxy-4-quinolone Isolated from Melochia tomentosa L. Abel A. Arroyo Aguilar, Gabriela N. Ledesma, Bárbara Tirloni, Teodoro S. Kaufman y Enrique L. Larghi. Synthesis 51, 4253-4262 (2019).

A Ruthenium-Catalyzed C‒H Activation Strategy as an Efficient Shortcut in the Total Synthesis of 6,8-Dimethoxy-1,3-dimethylisoquinoline, Santiago Fonzo, Didier F. Vargas y Teodoro S. Kaufman. Synthesis 51, 3908-3914 (2019).

A Concise Friedländer/Buchwald-Hartwig Approach to the Total Synthesis of Quindoline, a Bioactive Natural Indoloquinoline Alkaloid, and Toward the Unnatural 10-Methylquindoline, María V. Méndez, Sebastian O. Simonetti, Teodoro S. Kaufman y Andrea B. J. Bracca. New J. Chem. 43, 10803-10813 (2019).

Synthesis and Antifungal Activity of 4- and 6-(1H-pyrrol -1-yl)coumarins, and their Thiocyanato Derivatives, Nathan P. Brites, Marina C. Dilelio, Guilherme M. Martins, Gabriele do Carmo, Ademir F. Morel, Teodoro S. Kaufman y Claudio C. Silveira. ChemistrySelect 4, 5398 -5406 (2019).

Synthesis and Photophysical Properties of 1,4-Dihydro-2H,5H-chromeno[4,3-d][1,3]oxazin-5-ones, and Derivati-ves Containing Tethered 1,2,3-Triazoles, from 4-Amino coumarins, Marina C. Dilelio, Nathan P. Brites, Larissa A. Vieira, Bernardo Almeida Iglesias, Claudio C. Silveira y Teodoro S. Kaufman. Synthesis 00, 000-000 (2019). En prensa. DOI: 10.1055/s-0037-1612428.

A Convenient and Atom-economic One-pot SeCl2- Mediated Synthesis of 2-Arylselenopheno[2,3-b]indoles and their Antifungal Activity, Guilherme A. M. Martins, Gabriele do Carmo, Ademir F. Morel, Teodoro S. Kaufman y Claudio C. Silveira. Asian J. Org. Chem. 8, 369-375 (2019).

Concise Synthesis of the ABC-ring System of the Azafluoranthene, Tropoisoquinoline and Proaporphine Alkaloids. An Olefin Hydroacylation/Pomeranz-Fritsch Cyclization Approach. Didier F. Vargas, Enrique L. Larghi y Teodoro S. Kaufman. Synthesis 51, 2030-2038 (2019). Seleccionado para ser destacado en Synform.

Total Synthesis and Cytotoxic Activity of 6,8-Dimethoxy-1,3-dimethylisoquinoline, Isolated from Ancistrocladus tectorius. A 6π-Azaelectrocyclization Approach, Iván Cortés, Carla M. Borini Etichetti, Javier E. Girardini, Andrea B. J. Bracca y Teodoro S. Kaufman. Synthesis 51, 433-440 (2019).

The 6π-Azaelectrocyclization of Azatrienes. Synthetic Applications in Natural Products, Bioactive Heterocycles, and Related Fields, Didier F. Vargas, Enrique L. Larghi y Teodoro S. Kaufman. Nat. Prod. Rep. 39, 354-401 (2019).

Publicaciones 2018

Synthesis of polysubstituted 3-methyl isoquinolines through the 6π-electron cyclization/elimination of 1-azatrienes derived from 1,1-dimethylhydrazine". Didier F. Vargas, Enrique L. Larghi y Teodoro S. Kaufman. Eur. J. Org. Chem. 5605-5614 (2018).

Total Synthesis of Waltherione F, a Non-Rutaceous 3-Methoxy-4-Quinolone, Isolated from Waltheria indica L. F. Abel A. Arroyo Aguilar, Santiago J. Bolívar Ávila, Teodoro S. Kaufman y Enrique L. Larghi. Org. Lett. 20, 5058-5061 (2018).

Chemometrics-Assisted Study of the Interconversion between the Crystalline Forms of Nimodipine. Natalia L. Calvo, Marina Antonio, Naira M. Balzaretti, Teodoro S. Kaufman y Rubén M. Maggio. J. Pharm. Biomed. Anal. 158, 461-470 (2018).

A Convenient and Eco-friendly Cerium(III) Chloride-Catalyzed Synthesis of Methoxime Derivatives of Aromatic Aldehydes and Ketones. Iván Cortés, Teodoro S. Kaufman y Andrea B. J. Bracca. RS Open Sci. 5, 180279 (2018).

The 6π-Azaelectrocyclization of Azatrienes. Synthetic Applications in Natural Products, Bioactive Heterocycles, and Related Fields". Didier F. Vargas, Enrique L. Larghi y Teodoro S. Kaufman. Nat. Prod. Rep. 00, 000-000 (2018). En prensa. Doi: 10.1039/C8NP00014J.

Photophysical and Photochemical Properties of 3-Methylpterin as a New and More Stable Pterin-type Photosensitizer. Sandra Estébanez, Carolina Lorente, Teodoro S. Kaufman, Enrique L. Larghi, Andrés H. Thomas y Mariana P. Serrano. Photochem. Photobiol. 94, 881-889 (2018).

SeCl2-Mediated Approach Toward Indole-Containing Polysubstituted Selenophenes. Guilherme M. Martins, Davi F. Back, Teodoro S. Kaufman y Claudio C. Silveira. J. Org. Chem. 83, 3252-3264 (2018).

Isolation, Synthesis and Biological Activity of Quindoline, a Valuable Indoloquinoline Natural Product and Useful Key Intermediate. María V. Méndez, Andrea B. J. Bracca y Teodoro S. Kaufman. Synthesis 50, 1417-1429 (2018).

Activity of the Pterophyllins 2 and 4 Against Fruit Pathogenic Fungi. Comparison with a Synthetic Analog and Related Heterocyclic Intermediates", Jorgelina L. Pergomet, Melina G. Di Liberto, Marcos G. Derita, Andrea B. J. Bracca y Teodoro S. Kaufman. Fitoterapia 125, 98-105 (2018).

Characterization of Pharmaceutically Relevant Materials at the Solid State Employing Chemometrics Methods. Natalia L. Calvo, Rubén M. Maggio y Teodoro S. Kaufman. J. Pharm. Biomed. Anal. 147, 538-564 (2018).

Chemometrics-assisted Solid-state Characterization of Pharmaceutically Relevant Materials. Polymorphic Substances. Natalia L. Calvo, Rubén M. Maggio y Teodoro S. Kaufman. J. Pharm. Biomed. Anal. 147, 518-537 (2018).